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Comparison of bipolar disorder and schizophrenia
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Comparison of bipolar disorder and schizophrenia : ウィキペディア英語版
Comparison of bipolar disorder and schizophrenia

Both schizophrenia and bipolar disorder are characterized as psychiatric disorders in the Diagnostic and Statistical Manual of Mental Disorders fifth edition (DSM-5). Schizophrenia is a primary psychotic disorder, and bipolar disorder is a primary mood disorder but can also involve psychosis. However, because of some similar symptoms, differentiating between the two can sometimes be difficult; indeed, there is an intermediate diagnosis schizoaffective disorder.
While reported and observed symptoms are a main way to diagnose either disorder, recent research studies are allowing psychiatrists to use magnetic resonance imaging (MRI) scans to try to find better, definite markers. Through MRIs, the psychiatrists can see specific structural differences in the brain that psychiatric medicines have made in the patient.〔("Long-term Antipsychotic Treatment and Brain Volumes:A Longitudinal Study of First-Episode Schizophrenia" Authors Beng-Choon Ho, MRCPsych; Nancy C. Andreasen, MD, PhD; Steven Ziebell, BS; Ronald Pierson, MS; Vincent Magnotta, PhD. February 7, 2011 )〕 These differences include volume of gray matter, neuropathological size differences variations, and cortical thickness, which then associated with cognitive differences on tests. These differences may sometimes be seen throughout the lifespan of the diseases, and often occur soon after the initial episode. Although the diseases are different, some of their treatments are similar, because of some shared symptoms.
== Etiology and epidemiology ==
Both bipolar disorder and schizophrenia appear to result from gene–environment interaction. Evidence from numerous family and twin studies indicates a shared genetic etiology between schizophrenia and bipolar disorder.〔 〕〔 〕 Geoffroy, Etain, and Houenou note that the largest family study available found a combined heritability for bipolar disorder and schizophrenia of approximately 60%, with environmental factors accounting for the remainder.〔 Genetic contributions to schizoaffective disorder appear to be entirely shared with those contributing to schizophrenia and mania.〔
Bipolar I disorder and schizophrenia each occur in approximately 1% of the population; schizoaffective disorder is estimated to occur in less than 1% of the population.〔

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